The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2017
Filed:
Jun. 12, 2015
Waters Technologies Corporation, Milford, MA (US);
Scott J Geromanos, Middletown, NJ (US);
Steven J Ciavarini, Natick, MA (US);
Waters Technologies Corporation, Milford, MA (US);
Abstract
A method of mass spectrometry comprises ionizing a sample and obtaining mass spectral data relating to a plurality of ion detection events. The method then comprises applying match tolerances for mass to charge ratio (m/z), chromatographic retention time (t), and ion mobility drift time (t), to the ion detection events in order to determine possible charge state connections. The method also comprises constructing a tentative isotope chain and querying ion detection events for a match to the tentative isotope chain. Once a tentative isotope chain has been constructed, the method further comprises determining a corresponding theoretical molecular mass and a corresponding theoretical isotopic distribution, querying one or more lookup tables and returning one or more parameters (New X, New X', Δ New X′) related to the fractional mass to charge ratio (f) and at least one of: ion mobility drift time (t); and nominal mass to charge ratio (N), of the ion detection events, and using the one or more parameters (New X, New X′, Δ New X′) to determine a unique charge state of the ions.