The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 15, 2017

Filed:

Dec. 28, 2012
Applicant:

Washington State University Research Foundation, Pullman, WA (US);

Inventors:

Michael K. Skinner, Pullman, WA (US);

Carlos M. Guerrero-Bosagna, Pullman, WA (US);

Assignee:

Washington State University, Pullman, WA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); G06F 19/22 (2011.01); G06F 19/18 (2011.01);
U.S. Cl.
CPC ...
G06F 19/22 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6869 (2013.01); G06F 19/18 (2013.01);
Abstract

CpG densities and sequence motifs that are characteristic of regions of DNA associated with epimutations and control of epimutations are provided. Such regions include, within approximately 400 (or fewer) base pairs, at least one, usually two, and preferably all three of the following features: i) a CpG density of 15% or less; ii) the presence of the sequence motif ATTTGTTTTTTCTTTTnT (SEQ ID NO: 1) where n is A, T, C or G, and statistically relevant variants thereof; and iii) the presence of the sequence motif GGGGGnGGGG (SEQ ID NO: 2), where n is A, T, C or G, and statistically relevant variants thereof.


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