The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2017
Filed:
Dec. 14, 2012
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Stefan Becker, Darmstadt, DE;
Tim Heiseler, Rossdorf, DE;
Alexander Maass, Darmstadt, DE;
Harald Kolmar, Muehltal-Trautheim, DE;
Assignee:
Merck Patents GmbH, Darmstadt, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 30/08 (2006.01); G01N 33/543 (2006.01); C12N 15/10 (2006.01); G01N 33/532 (2006.01); G01N 33/542 (2006.01); G01N 33/554 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54353 (2013.01); C12N 15/1037 (2013.01); C12N 15/1086 (2013.01); G01N 33/532 (2013.01); G01N 33/542 (2013.01); G01N 33/554 (2013.01); C40B 30/08 (2013.01);
Abstract
A generally applicable method for the selective covalent attachment of a reporter molecule to a replicating entity that allows one to obtain specific binders from a single round of library screening is disclosed. For example, selective biotinylation of phage particles and yeast cells displaying a binder to any given target can be achieved via application of a coupled enzyme reaction that includes a peroxidase, an oxidase and a catalase.