The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2017
Filed:
Jul. 20, 2015
Applicant:
Hough Ear Institute, Oklahoma City, OK (US);
Inventor:
Richard D. Kopke, Oklahoma City, OK (US);
Assignee:
HOUGH EAR INSTITUTE, Oklahoma City, OK (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/713 (2006.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61P 27/16 (2006.01); C12N 15/113 (2010.01); A61K 41/00 (2006.01); A61K 9/50 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/0019 (2013.01); A61K 9/0046 (2013.01); A61K 9/5115 (2013.01); A61K 9/5153 (2013.01); A61K 31/713 (2013.01); A61K 41/00 (2013.01); C12N 15/1137 (2013.01); A61K 9/5031 (2013.01); C12N 2310/14 (2013.01);
Abstract
A composition and method for replacement and regeneration of hair cells of the inner ear is provided. The composition comprises an active agent in an amount effective to decrease Hes1 gene expression in a tissue of the inner ear. The active agent can be short interfering RNA (siRNA) molecules encapsulated in a biodegradable nanoparticle. The method involves administering a solution to the inner ear where the solution contains an active agent in an amount effective to decrease Hes1 gene expression.