The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 15, 2017

Filed:

Dec. 19, 2011
Applicants:

Bahram Valamehr, Granada Hills, CA (US);

Ramzey Abujarour, San Diego, JO;

Peter Flynn, La Jolla, CA (US);

Inventors:

Bahram Valamehr, Granada Hills, CA (US);

Ramzey Abujarour, San Diego, JO;

Peter Flynn, La Jolla, CA (US);

Assignee:

Fate Therapeutics, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0607 (2013.01); C12N 5/0696 (2013.01); C12N 2501/148 (2013.01); C12N 2501/415 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/605 (2013.01); C12N 2501/606 (2013.01); C12N 2501/608 (2013.01); C12N 2501/727 (2013.01); C12N 2501/999 (2013.01); C12N 2502/99 (2013.01); C12N 2506/1307 (2013.01); C12N 2533/52 (2013.01); C12N 2533/54 (2013.01);
Abstract

The invention provides cell culture conditions for culturing stem cells, including feeder-free conditions for generating and culturing human induced pluripotent stem cells (iPSCs). More particularly, the invention provides a culture platform that allows long-term culture of pluripotent cells in a feeder-free environment; reprogramming of cells in a feeder-free environment; single-cell dissociation of pluripotent cells; cell sorting of pluripotent cells; maintenance of an undifferentiated status; improved efficiency of reprogramming; and generation of a naïve pluripotent cell.


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