The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2017
Filed:
Sep. 21, 2015
Applicant:
Duquesne University of the Holy Spirit, Pittsburgh, PA (US);
Inventor:
Aleem Gangjee, Allison Park, PA (US);
Assignee:
Duquesne University of the Holy Ghost, Pittsburgh, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/04 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 491/048 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); C07D 487/04 (2013.01); C07D 491/04 (2013.01); C07D 491/048 (2013.01);
Abstract
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a single agent of potent vascular endothelial growth factor receptor inhibitory activity as well as antitubulin activity. Water soluble salts of these compositions are also described. Methods of treating a patient having cancer, macular degeneration, and arthritis with the compositions and salts thereof of the present invention are disclosed.