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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9732044 B1

PDFFull Text
Date of Patent:
Aug. 15, 2017

Filed:

Aug. 15, 2016

N-(pyrid-4-yl)amides and n-(pyrimidin-4-yl)amides and their pharmaceutical and cosmetic use

Applicant:

Galderma Research & Development, Biot, FR;

Inventor:

Cédric Poinsard, Le Rouret, FR;

Assignee:

GALDERMA RESEARCH & DEVELOPMENT, Biot, FR;

Attorney:

Dentons US LLP

Primary Examiner:

Deepak Rao

Int. Cl.
CPC ...
C07D 239/47 (2006.01); A61K 31/505 (2006.01); C07D 213/81 (2006.01); A61Q 7/00 (2006.01); C07D 213/75 (2006.01); C07D 405/12 (2006.01); C07D 239/52 (2006.01); C07D 239/48 (2006.01); A61K 8/49 (2006.01); A61Q 7/02 (2006.01); A61K 8/69 (2006.01); A61Q 19/00 (2006.01); C07D 213/79 (2006.01); C07D 213/84 (2006.01); A61Q 5/00 (2006.01);
U.S. Cl.
CPC ...
C07D 239/47 (2013.01); A61K 8/498 (2013.01); A61K 8/4926 (2013.01); A61K 8/4953 (2013.01); A61K 8/69 (2013.01); A61Q 5/008 (2013.01); A61Q 7/00 (2013.01); A61Q 7/02 (2013.01); A61Q 19/008 (2013.01); C07D 213/75 (2013.01); C07D 213/79 (2013.01); C07D 213/81 (2013.01); C07D 213/84 (2013.01); C07D 239/48 (2013.01); C07D 239/52 (2013.01); C07D 405/12 (2013.01);
Abstract

The present invention relates generally to the field of pharmaceuticals and cosmetics. More specifically, the present invention pertains to certain N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides of the following formula which are potent modulators (e.g., inhibitors) of an androgen receptor, and which are useful, for example, in therapy, for example, in the treatment of a dermatological disease or disorder; a disease or disorder of the sebaceous gland(s); acne; hyperseborrhoea; oily skin; seborrhoeic dermatitis; hyperpilosity or hirsutism; atopic dermatitis; or androgenic alopecia; especially acne. The present invention also relates to compositions (e.g., pharmaceutical compositions, cosmetic compositions) comprising the compounds; methods of preparing the compositions; methods of modulating (e.g., inhibiting) an androgen receptor using the compounds and/or compositions; and medical and/or cosmetic use of the compounds and compositions.

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