The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 15, 2017

Filed:

May. 06, 2015
Applicant:

Trustees of Tufts College, Medford, MA (US);

Inventors:

David L. Kaplan, Concord, MA (US);

Xianyan Wang, Acton, MA (US);

Assignee:

Trustees of Tufts College, Medford, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61L 27/22 (2006.01); A61L 27/40 (2006.01); C09D 189/00 (2006.01); A61L 31/10 (2006.01); A61L 15/32 (2006.01); A61L 31/16 (2006.01); A61L 15/44 (2006.01); A61L 27/36 (2006.01); A61L 27/50 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61L 31/10 (2013.01); A61L 15/32 (2013.01); A61L 15/44 (2013.01); A61L 27/3604 (2013.01); A61L 27/50 (2013.01); A61L 31/16 (2013.01); A61L 2300/416 (2013.01); A61L 2300/43 (2013.01); A61L 2400/12 (2013.01); A61L 2400/18 (2013.01);
Abstract

The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.


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