The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2017
Filed:
Aug. 06, 2015
Applicants:
Pharmacyclics Llc, Sunnyvale, CA (US);
Janssen Pharmaceutica NV, Beerse, BE;
Inventors:
Hsu-Ping Kuo, Sunnyvale, CA (US);
Hsin-Kang Hsieh, San Jose, CA (US);
Betty Chang, Cupertino, CA (US);
Ling Xue, Beijing, CN;
Sriram Balasubramanian, North Wales, PA (US);
Leo Cheung, Fremont, CA (US);
Assignees:
Pharmacyclics LLC, Sunnyvale, CA (US);
Janssen Pharmaceutica NV, Beerse, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61K 31/4164 (2006.01); A61K 31/4196 (2006.01); A61K 31/426 (2006.01); A61K 31/454 (2006.01); A61K 45/06 (2006.01); A61K 38/00 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/21 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/4164 (2013.01); A61K 31/4196 (2013.01); A61K 31/426 (2013.01); A61K 31/454 (2013.01); A61K 38/005 (2013.01); A61K 38/191 (2013.01); A61K 38/2013 (2013.01); A61K 38/21 (2013.01); A61K 45/06 (2013.01);
Abstract
Disclosed herein are methods, compositions, and kits for treating a B-cell malignancy comprising administering a combination of a BTK inhibitor (e.g. ibrutinib) and a PIM inhibitor. Also disclosed herein are methods, compositions, and kits for treating a BTK-resistant B-cell malignancy comprising administering a combination of a BTK inhibitor (e.g. ibrutinib) and a PIM inhibitor.