The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2017
Filed:
Aug. 04, 2015
Applicant:
I.e.r.f.c. European Institute for Cystic Fibrosis Research, Milan, IT;
Inventors:
Luigi Maiuri, Milan, IT;
Valeria Raia, Milan, IT;
Fabio Borella, Milan, IT;
Guido Kroemer, Milan, IT;
Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 31/145 (2006.01); A61K 31/352 (2006.01); A61K 31/047 (2006.01); A61K 31/05 (2006.01); A61K 31/13 (2006.01); A61K 31/192 (2006.01); A61K 31/198 (2006.01); A61K 31/357 (2006.01); A61K 31/37 (2006.01); A61K 31/7034 (2006.01); A61K 45/06 (2006.01); A61K 31/366 (2006.01);
U.S. Cl.
CPC ...
A61K 31/47 (2013.01); A61K 31/047 (2013.01); A61K 31/05 (2013.01); A61K 31/13 (2013.01); A61K 31/145 (2013.01); A61K 31/192 (2013.01); A61K 31/198 (2013.01); A61K 31/352 (2013.01); A61K 31/357 (2013.01); A61K 31/366 (2013.01); A61K 31/37 (2013.01); A61K 31/7034 (2013.01); A61K 45/06 (2013.01);
Abstract
There is disclosed a combination of inhibitors of Tissue Transglutaminase (TG2), inhibitors of reactive oxygen species (ROS) and CFTR channel activators (potentiators) for separate, sequential or simultaneous administration to CF patients carrying the ΔF508-CFTR mutation, and pharmaceutical compositions thereof.