The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 08, 2017

Filed:

Dec. 13, 2013
Applicant:

Tla Targeted Immunotherapies Ab, Stockholm, SE;

Inventors:

Ola Winqvist, Uppsala, SE;

Graham Cotton, Edinburgh, GB;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61M 37/00 (2006.01); A61K 39/395 (2006.01); A61K 39/40 (2006.01); G01N 33/566 (2006.01); A61M 1/36 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
G01N 33/566 (2013.01); A61M 1/3679 (2013.01); G01N 33/56972 (2013.01); G01N 2333/70596 (2013.01); G01N 2333/7158 (2013.01); G01N 2800/065 (2013.01);
Abstract

A method of diagnosing, monitoring progression of, or monitoring treatment of inflammatory bowel disease comprises determining the levels of CD14HLA-DRmonocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9 in a sample obtained from a subject, wherein high levels of CD14HLA-DRmonocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9, or increased levels of CD14HLA-DRmonocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9 compared to control, indicate the presence or progression of inflammatory bowel disease. Similar methods for diagnosing irritable bowel syndrome are also described. Various companion therapeutic methods and useful binding reagents are also described.


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