The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2017
Filed:
Mar. 08, 2016
Ablynx N.v., Zwijnaarde, BE;
Marie-Paule Lucienne Armanda Bouche, Gentbrugge, BE;
Peter Vanlandschoot, Bellem, BE;
Erwin Sablon, Merchtem, BE;
Erik Depla, Destelbergen, BE;
Stefan De Buck, Buesserach, CH;
Xavier Saelens, Leper, BE;
Bert Schepens, Drongen, BE;
Karen Silence, Overijse, BE;
Mark Vaeck, Hofstade, BE;
Paul M. P. Van Bergen En Henegouwen, Utrecht, NL;
Hans De Haard, Oudelande, NL;
Ablynx N.V., Zwijnaarde, BE;
Abstract
In one aspect, the invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of cells. The invention further relates to anti-IgE therapeutic molecules. In one aspect, the present invention relates to a method wherein an immunoglobulin single variable domain (such as a Nanobody) and/or construct thereof are absorbed in pulmonary tissue. More particularly, the invention provides systemic delivery of an immunoglobulin single variable domain and/or construct thereof via the pulmonary route.