The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2017
Filed:
Sep. 24, 2015
Applicant:
Aveo Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Lorena Lerner, Newton Centre, MA (US);
Sandra Abbott, Boston, MA (US);
Ailin Bai, Newton, MA (US);
Ting Chen, Acton, MA (US);
Maria I. Chiu, Newton Centre, MA (US);
Qing Liu, Acton, MA (US);
Laura Poling, Boston, MA (US);
Nianjun Tao, Brighton, MA (US);
Solly Weiler, Newton, MA (US);
Zhigang Weng, Brookline, MA (US);
William M. Winston, Jr., Marlborough, MA (US);
Jeno Gyuris, Lincoln, MA (US);
Assignee:
AVEO Pharmaceuticals, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/22 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01);
Abstract
Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.