The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 08, 2017

Filed:

Oct. 12, 2016
Applicant:

Northwestern University, Evanston, IL (US);

Inventors:

Denana U. Miodragovic, Chicago, IL (US);

Thomas V. O'Halloran, Chicago, IL (US);

Assignee:

Northwestern University, Evanston, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/70 (2006.01); C07F 15/00 (2006.01); A61K 31/282 (2006.01); A61K 31/285 (2006.01); A61K 31/29 (2006.01); A61K 31/295 (2006.01); C07F 15/04 (2006.01);
U.S. Cl.
CPC ...
C07F 15/0013 (2013.01); A61K 31/282 (2013.01); A61K 31/285 (2013.01); A61K 31/29 (2013.01); A61K 31/295 (2013.01); C07F 15/0066 (2013.01); C07F 15/0093 (2013.01); C07F 15/045 (2013.01);
Abstract

Disclosed herein are conjugates that include a ligand, and a compound having the structure of formula (I) M is Pt, Pd or Ni; Q is As, Sb or Bi; Zis N; Zis O or S; Land Lare independently C(O), C—Ror C—R; X is a Lewis base; Yand Yare independently selected from —OR, —OR, —SRand —SR, wherein Rand Rare independently selected from hydrogen, halogen, cyano, keto, ester, ether, thiol, thioether, thioester, imino, C-Calkyl, C-Calkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C-Ccycloalkyl, heteroaryl, and C-Cheterocycloalkyl; and Rand Rare independently selected from hydrogen, C-Calkyl, C-Calkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C-Ccycloalkyl, heteroaryl, and C-Cheterocycloalkyl.


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