The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2017
Filed:
Mar. 14, 2014
President and Fellows of Harvard College, Cambridge, MA (US);
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, CN;
Tufts University, Boston, MA (US);
University of Houston, Houston, TX (US);
Junying Yuan, Newton, MA (US);
Alexei Degterev, Brookline, MA (US);
Gregory D. Cuny, Houston, TX (US);
Presidents and Fellows of Harvard College, Cambridge, MA (US);
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, CN;
Tufts University, Boston, MA (US);
University of Houston, Houston, TX (US);
Abstract
The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.