The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 08, 2017

Filed:

Sep. 18, 2014
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

T. G. Murali Dhar, Newtown, PA (US);

Jingwu Duan, Yardley, PA (US);

Hua Gong, Newtown, PA (US);

Bin Jiang, Bryn Mawr, PA (US);

Zhonghui Lu, King of Prussia, PA (US);

David S. Weinstein, East Windsor, NJ (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/47 (2006.01); C07D 417/06 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 413/14 (2006.01); C07D 215/58 (2006.01); C07D 413/06 (2006.01);
U.S. Cl.
CPC ...
C07D 417/06 (2013.01); C07D 215/58 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 413/06 (2013.01); C07D 413/14 (2013.01);
Abstract

Described are RORγ modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The invention includes stereoisomeric forms of the compounds of formula I, including stereoisomerically-pure, scalemic and racemic form, as well as tautomers thereof. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.


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