The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2017
Filed:
Sep. 28, 2014
Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Lianyungang, CN;
Centaurus Biopharma Co., Ltd., Beijing, CN;
Lianyungang Runzhong Pharmaceutical Co., Ltd., Lianyungang, CN;
Dengming Xiao, Beijing, CN;
Yan Zhu, Beijing, CN;
Yuandong Hu, Beijing, CN;
Huting Wang, Beijing, CN;
Jijun Li, Beijing, CN;
Yong Peng, Beijing, CN;
Hui Zhang, Beijing, CN;
Hong Luo, Beijing, CN;
Fansheng Kong, Beijing, CN;
Yongxin Han, Beijing, CN;
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., Jiangsu, CN;
CENTAURUS BIOPHARMA CO., LTD., Beijing, CN;
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD., Jiangsu, CN;
Abstract
The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo.