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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9725436 B1

PDFFull Text
Date of Patent:
Aug. 08, 2017

Filed:

Sep. 15, 2014

Cytochrome p450 inhibitors and their method of use

Applicant:

Cortendo Ab (Publ), Trevose, PA (US);

Inventors:

Benjamin Eric Blass, Eagleville, PA (US);

Magid A Abou-Gharbia, Exton, PA (US);

Wayne E. Childers, New Hope, PA (US);

Pravin Iyer, Bangaluru, IN;

Joshodeep Boruwa, Mallapur, IN;

Assignee:

CORTENDO AB (PUBL), Trevose, PA (US);

Attorneys:

Reed Smith LLP

Matthew S. Gibson

Primary Examiner:

Deepak Rao

Int. Cl.
CPC ...
C07D 401/10 (2006.01); C07D 213/26 (2006.01); A61K 31/4418 (2006.01); C07D 401/12 (2006.01); C07D 213/71 (2006.01); C07D 233/60 (2006.01); C07D 233/61 (2006.01); C07D 233/84 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 213/30 (2006.01); C07D 213/38 (2006.01); C07D 213/65 (2006.01); C07D 213/56 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 31/4418 (2013.01); C07D 213/26 (2013.01); C07D 213/30 (2013.01); C07D 213/38 (2013.01); C07D 213/56 (2013.01); C07D 213/65 (2013.01); C07D 213/71 (2013.01); C07D 233/60 (2013.01); C07D 233/61 (2013.01); C07D 233/84 (2013.01); C07D 401/10 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01);
Abstract

Embodiments of the present invention relate to novel cytochrome P450 inhibitors and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the production of cortisol that include metabolic syndrome, obesity, headache, depression, hypertension, diabetes mellitus, Cushing's Syndrome, pseudo-Cushing syndrome, cognitive impairment, dementia, heart failure, renal failure, psoriasis, glaucoma, cardiovascular disease, cancer, stroke or incidentalomas.

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