The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 08, 2017

Filed:

Mar. 04, 2014
Applicants:

The University of Mississippi, University, MS (US);

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Inventors:

Christopher R. McCurdy, Oxford, MS (US);

Christophe Mesangeau, Hellemmes, FR;

Frederick T. Chin, Sunnyvale, CA (US);

Michelle L. James, Menlo Park, CA (US);

Bin Shen, Mountain View, CA (US);

Sanjiv Gambhir, Portola Valley, CA (US);

Sandip Biswal, Stanford, CA (US);

Deepak Behera, Fremont, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/428 (2006.01); C07D 209/48 (2006.01); C07D 235/26 (2006.01); C07D 263/58 (2006.01); C07D 277/68 (2006.01); C07D 403/06 (2006.01); C07D 405/04 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 417/06 (2006.01); C07D 491/107 (2006.01); C07D 491/20 (2006.01); A61K 51/04 (2006.01); C07D 265/36 (2006.01); C07D 209/08 (2006.01); C07D 209/10 (2006.01); C07D 277/70 (2006.01); C07D 279/16 (2006.01); C07D 295/13 (2006.01); C07D 277/74 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0468 (2013.01); A61K 31/428 (2013.01); A61K 51/0453 (2013.01); A61K 51/0455 (2013.01); A61K 51/0459 (2013.01); C07D 209/08 (2013.01); C07D 209/10 (2013.01); C07D 209/48 (2013.01); C07D 235/26 (2013.01); C07D 263/58 (2013.01); C07D 265/36 (2013.01); C07D 277/68 (2013.01); C07D 277/70 (2013.01); C07D 277/74 (2013.01); C07D 279/16 (2013.01); C07D 295/13 (2013.01); C07D 403/06 (2013.01); C07D 405/04 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 417/06 (2013.01); C07D 491/107 (2013.01); C07D 491/20 (2013.01);
Abstract

A method for localizing and quantifying S1R role in nociceptive processing; for providing a guide to providing an analgesic therapy; of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders; or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III', or IV′:


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