The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2017
Filed:
Sep. 10, 2014
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Kerstin Kruger, Tutzing, DE;
Beat Amrein, Ruenenberg, CH;
Stefan Foser, Steinhausen, CH;
Kurt Lang, Penzberg, DE;
Friedrich Metzger, Freiburg, DE;
Joerg Thomas Regula, Munich, DE;
Andreas Schaubmar, Penzberg, DE;
Friederike Hesse, Munich, DE;
Klaus-Peter Kuenkele, Marzling, DE;
Martin Lanzendoerfer, Tutzing, DE;
HOFFMANN-LA ROCHE INC., Little Falls, NJ (US);
Abstract
A conjugate consisting of an insulin-like growth factor-1 (IGF-I) variant and one or two poly(ethylene glycol) group(s), characterized in that said IGF-I variant has an amino acid alteration at up to three amino acid positions 27, 37, 65, 68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is/are lysine and amino acid 27 is a polar amino acid but not lysine, is conjugated via the primary amino group(s) of said lysine(s) and said poly(ethylene glycol) group(s) have an overall molecular weight of from 20 to 100 kDa is disclosed. This conjugate is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease.