The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 08, 2017

Filed:

Dec. 10, 2013
Applicant:

National Center for Geriatrics and Gerontology, Obu-shi, Aichi, JP;

Inventors:

Misako Nakashima, Obu, JP;

Koichiro Iohara, Obu, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61L 27/38 (2006.01); C12N 5/0775 (2010.01); A61K 38/19 (2006.01); A61K 35/32 (2015.01); A61C 5/50 (2017.01); A61K 35/28 (2015.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61C 5/50 (2017.02); A61K 35/32 (2013.01); A61K 38/193 (2013.01); A61L 27/3633 (2013.01); A61L 27/3834 (2013.01); A61L 27/3865 (2013.01); C12N 5/0664 (2013.01); A61L 2430/12 (2013.01);
Abstract

Disclosed is a root canal filler for non-extracted tooth which causes no internal resorption or external resorption in a tooth with complete root formation, shows no odontoclast, and contributes to the regeneration of a dental tissue in which odontoblasts are smoothly aligned on the dentin wall. After pulpectomy or enlargement/cleaning of an infected root canal, a root canal filler for non-extracted tooth, which comprises tooth pulp stem cells and an extracellular matrix, is inserted into the apical side of the root canal of the non-extracted tooth. The tooth pulp stem cells may be, for example, dental pulp CXCR4-positive cells. It is preferred to attach, to the crown side of the root canal, migration factor(s) including at least one factor selected from among a cell migration factor, a cell proliferation factor, a neurotrophic factor and an angiogenic factor.


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