The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2017
Filed:
Mar. 19, 2015
Terumo Kabushiki Kaisha, Shibuya-ku, Tokyo, JP;
Kansai Medical University Educational Corporation, Hirakata, Osaka, JP;
Keiko Yamashita, Kanagawa, JP;
Yasuo Kurosaki, Kanagawa, JP;
Makoto Harumoto, Kanagawa, JP;
Kyoko Shimamura, Kanagawa, JP;
Masaki Kaibori, Osaka, JP;
Yoshiro Araki, Osaka, JP;
Masanori Kon, Osaka, JP;
Seiji Ito, Osaka, JP;
TERUMO KABUSHIKI KAISHA, Tokyo, JP;
KANSAI MEDICAL UNIVERSITY EDUCATIONAL CORPORATION, Osaka, JP;
Abstract
A long-lasting, controlled-release local anesthetic liposome preparation is produced by: providing a liposome composition, which is obtained by mixing, in a water-miscible organic solvent, a first aqueous phase solution with a water-miscible organic solution, in which a phospholipid and cholesterol are contained at a defined total concentration, at a defined ratio by volume thereby obtaining an emulsion wherein a total concentration of the phospholipid and cholesterol in the mixed phase is at 15 w/v % to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution to obtain a liposome composition wherein an ion gradient is formed between an internal-region aqueous phase of a liposome membrane made of the first aqueous phase solution and an external-region aqueous phase of the liposome membrane made of the second aqueous phase solution; and encapsulating a local anesthetic in the internal-region aqueous phase according to a remote loading method.