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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9719087 B1

PDFFull Text
Date of Patent:
Aug. 01, 2017

Filed:

Jan. 08, 2015

Micro-rna family that modulates fibrosis and uses thereof

Applicant:

The Board of Regents, the University of Texas System, Austin, TX (US);

Inventors:

Eric N. Olson, Dallas, TX (US);

Eva van Rooij, Utrecht, NL;

Assignee:

THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);

Attorney:
Primary Examiner:

J E Angell

Int. Cl.
CPC ...
C12N 15/113 (2010.01); A01K 67/027 (2006.01); A61K 38/22 (2006.01); C12N 9/16 (2006.01); C12N 15/85 (2006.01); A61K 31/7105 (2006.01); A61K 31/712 (2006.01); A61K 31/7125 (2006.01); A61K 31/713 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 31/07 (2006.01); A61K 31/355 (2006.01); A61K 31/375 (2006.01); A61L 31/08 (2006.01); A61L 31/16 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A01K 67/0276 (2013.01); A61K 31/07 (2013.01); A61K 31/355 (2013.01); A61K 31/375 (2013.01); A61K 31/712 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 31/7125 (2013.01); A61K 38/2242 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61L 31/08 (2013.01); A61L 31/16 (2013.01); C12N 9/16 (2013.01); C12N 15/8509 (2013.01); A01K 2207/30 (2013.01); A01K 2217/052 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0375 (2013.01); A61L 2300/258 (2013.01); A61L 2300/45 (2013.01); A61L 2420/06 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/346 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/30 (2013.01); C12N 2320/31 (2013.01); C12N 2320/32 (2013.01); C12N 2330/10 (2013.01);
Abstract

The present invention relates to the identification of a microRNA family, designated miR-29-, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.

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