The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2017
Filed:
Aug. 21, 2015
Applicant:
Shire Human Genetic Therapies, Inc., Lexington, MA (US);
Inventors:
Ferenc Boldog, Lexington, MA (US);
Michael Heartlein, Lexington, MA (US);
Assignee:
Shire Human Genetic Therapies, Inc., Lexington, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); C12Y 301/06013 (2013.01);
Abstract
The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture.