The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 01, 2017

Filed:

Dec. 14, 2015
Applicant:

Merrimack Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Ulrik Nielsen, Quincy, MA (US);

Thomas Wickham, Groton, MA (US);

Birgit Schoeberl, Cambridge, MA (US);

Brian Harms, Roslindale, MA (US);

Bryan Linggi, Richland, WA (US);

Matthew Onsum, El Cerrito, CA (US);

Byron DeLaBarre, Cambridge, MA (US);

Shaun M. Lippow, San Francisco, CA (US);

Assignee:

Merrimack Pharmaceuticals, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 16/44 (2006.01); A61K 47/48 (2006.01); B82Y 5/00 (2011.01); C07K 14/475 (2006.01); C12N 15/62 (2006.01); A61K 45/06 (2006.01); C07K 16/46 (2006.01); C07K 14/47 (2006.01); C07K 14/485 (2006.01); C07K 14/65 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/44 (2013.01); A61K 45/06 (2013.01); A61K 47/48346 (2013.01); A61K 47/48415 (2013.01); A61K 47/48538 (2013.01); A61K 47/48723 (2013.01); B82Y 5/00 (2013.01); C07K 14/47 (2013.01); C07K 14/475 (2013.01); C07K 14/485 (2013.01); C07K 14/65 (2013.01); C07K 16/46 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2317/31 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C07K 2319/80 (2013.01);
Abstract

Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.


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