The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2017
Filed:
May. 27, 2015
Applicant:
Medimmune, Llc, Gaithersburg, MD (US);
Inventors:
Melissa Damschroder, Gaithersburg, MD (US);
Michael Oberst, Gaithersburg, MD (US);
Scott Hammond, Gaithersburg, MD (US);
Hui Feng, Potomac, MD (US);
Assignee:
MedImmune, LLC, Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/385 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07H 21/04 (2006.01); C12P 21/06 (2006.01); C12N 15/00 (2006.01); C12N 5/00 (2006.01); C07K 14/705 (2006.01); A61K 39/39 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70575 (2013.01); A61K 39/39 (2013.01); A61K 2039/55516 (2013.01); A61K 2039/6056 (2013.01); C07K 2319/30 (2013.01);
Abstract
The disclosure provides OX40L huIgG4 fusion polypeptide subunits comprising a human IgG4 Fc domain, a trimerization domain, and the receptor binding domain of Ox40 ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.