The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2017
Filed:
Mar. 13, 2014
Applicant:
Trustees of Boston University, Boston, MA (US);
Inventors:
Douglas Ewen Cameron, Boston, MA (US);
James J. Collins, Newton Centre, MA (US);
Assignee:
TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/04 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61K 38/06 (2006.01); C07K 5/097 (2006.01); C07K 14/30 (2006.01); G01N 33/50 (2006.01); C07K 5/083 (2006.01); C07K 5/087 (2006.01); C07K 5/09 (2006.01); C07K 5/093 (2006.01); C07K 5/103 (2006.01); C07K 5/107 (2006.01); C07K 5/11 (2006.01); C07K 5/117 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
C07K 5/0823 (2013.01); C07K 5/0806 (2013.01); C07K 5/0812 (2013.01); C07K 5/0817 (2013.01); C07K 5/0819 (2013.01); C07K 5/101 (2013.01); C07K 5/1016 (2013.01); C07K 5/1019 (2013.01); C07K 5/1024 (2013.01); C07K 7/06 (2013.01); C07K 14/30 (2013.01); G01N 33/502 (2013.01); C07K 2319/95 (2013.01); G01N 2333/30 (2013.01); G01N 2500/10 (2013.01);
Abstract
The methods and compositions described herein relate, in part, to the generation of a synthetic degradation system inthat provides tunable control of the protein level of targeted genes by using components of thetmRNA system. Provided herein are degradation tag variants that permit independent control of both the initial level and inducible degradation rate of attached proteins.