IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9718854 B1

PDFFull Text
Date of Patent:
Aug. 01, 2017

Filed:

Mar. 20, 2012

Selective glycosidase inhibitors and uses thereof

Applicants:

Ramesh Kaul, Burnaby, CA;

Ernest J. Mceachern, Burnaby, CA;

David J. Vocadlo, Burnaby, CA;

Yuanxi Zhou, Burnaby, CA;

Kun Liu, Rahway, NJ (US);

Harold G. Selnick, West Point, PA (US);

Zhongyong Wei, Beijing, CN;

Changwei Mu, Beijing, CN;

Yaode Wang, Beijing, CN;

Xiaona Wang, Beijing, CN;

Inventors:

Ramesh Kaul, Burnaby, CA;

Ernest J. McEachern, Burnaby, CA;

David J. Vocadlo, Burnaby, CA;

Yuanxi Zhou, Burnaby, CA;

Kun Liu, Rahway, NJ (US);

Harold G. Selnick, West Point, PA (US);

Zhongyong Wei, Beijing, CN;

Changwei Mu, Beijing, CN;

Yaode Wang, Beijing, CN;

Xiaona Wang, Beijing, CN;

Assignees:

Alectos Therapeutics Inc., Burnaby, CA;

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorney:

Clark & Elbing LLP

Primary Examiner:

Kristin Vajda

Int. Cl.
CPC ...
C07H 19/24 (2006.01); C07D 513/04 (2006.01); A61K 31/429 (2006.01); C12N 9/99 (2006.01); C12Q 1/34 (2006.01); C07H 9/06 (2006.01); C07H 11/00 (2006.01); C07H 13/12 (2006.01); C07H 15/04 (2006.01); C07H 15/12 (2006.01); C07H 15/18 (2006.01); C07H 15/203 (2006.01); C07H 15/207 (2006.01); C07H 17/02 (2006.01); C07H 17/04 (2006.01); A61K 31/7056 (2006.01);
U.S. Cl.
CPC ...
C07H 19/24 (2013.01); A61K 31/7056 (2013.01); C07D 513/04 (2013.01); C07H 9/06 (2013.01); C07H 11/00 (2013.01); C07H 13/12 (2013.01); C07H 15/04 (2013.01); C07H 15/12 (2013.01); C07H 15/18 (2013.01); C07H 15/203 (2013.01); C07H 15/207 (2013.01); C07H 17/02 (2013.01); C07H 17/04 (2013.01); C12N 9/99 (2013.01); C12Q 1/34 (2013.01); C12Y 302/01169 (2013.01);
Abstract

The invention provides compounds of formula (I) with substituents as specified in claimfor selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.

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