The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2017
Filed:
Apr. 16, 2015
Applicants:
Calitor Sciences, Llc, Newbury Park, CA (US);
Sunshine Lake Pharma Co., Ltd., Dongguan, Guangdong, CN;
Assignees:
CALITOR SCIENCES, LLC, Newbury Park, CA (US);
SUNSHINE LAKE PHARMA CO., LTD., Dongguan, Guangdong, CN;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/04 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/5383 (2006.01); A61K 45/06 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/5383 (2013.01); A61K 45/06 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C12N 9/12 (2013.01); C12Y 207/10001 (2013.01);
Abstract
The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases, especially Axl, Mer, c-Met and Ron. The invention also provides pharmaceutical compositions comprising the compound disclosed herein, and a method of preventing, treating or lessening the severity of a proliferative disorder in a patient with the compounds or the pharmaceutical compositions disclosed herein.