The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 01, 2017

Filed:

Aug. 30, 2016
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Merck Sharp & Dohme B.v., Haarlem, NL;

Inventors:

Adrianus Petrus Antonius De Man, Hurwenen, NL;

Jan-Gerard Sterrenburg, Renkum, NL;

Hans C. A. Raaijmakers, Eindhoven, NL;

Allard Kaptein, Zaltbommel, NL;

Arthur A. Oubrie, Wijchen, NL;

Johannes Bernardus Maria Rewinkel, Berghem, NL;

Christiaan Gerardus Johannes Maria Jans, Cuijk, NL;

Jacobus C. H. M. Wijkmans, Oss, NL;

Tjeerd A. Barf, Ravenstein, NL;

Alan B. Cooper, West Caldwell, NJ (US);

Ronald M. Kim, Summit, NJ (US);

Sobhana Babu Boga, Scotch Plains, NJ (US);

Hugh Y. Zhu, Warren, NJ (US);

Xiaolei Gao, Bridgewater, NJ (US);

Xin Yao, Westfield, NJ (US);

Rajan Anand, Fanwood, NJ (US);

Hao Wu, Shanghai, CN;

Shilan Liu, Shanghai, CN;

Chundao Yang, Shanghai, CN;

Abdul-Basit Alhassan, Scotch Plains, NJ (US);

James Wang, Westfield, NJ (US);

Younong Yu, East Brunswick, NJ (US);

Jian Liu, Edison, NJ (US);

Henry M. Vaccaro, South Plainfield, NJ (US);

Assignees:

MERCK SHARP & DOHME CORP., Rahway, NJ (US);

MERCK SHARP & DOHME B.V., Haarlem, NL;

Attorneys:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 497/02 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); A61K 31/437 (2006.01); A61K 31/4985 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61K 31/53 (2006.01); A61P 19/02 (2006.01); C07D 519/00 (2006.01); A61K 45/06 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/55 (2006.01); C07D 513/04 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4985 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 471/04 (2013.01); C07D 513/04 (2013.01); C07D 519/00 (2013.01);
Abstract

Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.


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