The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 01, 2017

Filed:

Jun. 29, 2016
Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Mark R. Player, Phoenixville, PA (US);

Raul Calvo, Royersford, PA (US);

Jinsheng Chen, Exton, PA (US);

Sanath Meegalla, Garnet Valley, PA (US);

Daniel J. Parks, Downingtown, PA (US);

William J. Parsons, Belle Mead, NJ (US);

Scott Ballentine, Lansdale, PA (US);

Shawn Branum, Easton, PA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/437 (2006.01); C07D 471/04 (2006.01); C07D 473/00 (2006.01); C07D 487/04 (2006.01); C07C 53/18 (2006.01); C07C 309/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07C 53/18 (2013.01); C07C 309/04 (2013.01); C07D 473/00 (2013.01); C07D 487/04 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.


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