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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9718817 B1

PDFFull Text
Date of Patent:
Aug. 01, 2017

Filed:

Apr. 15, 2015

Aryl and heteroaryl ether compounds as ror gamma modulators

Applicant:

Glenmark Pharmaceuticals S.a., La Chaux-de-Fonds, CH;

Inventors:

Sachin S. Chaudhari, Navi Mumbai, IN;

Abraham Thomas, Navi Mumbai, IN;

Ashok B. Kadam, Navi Mumbai, IN;

Sachin V. Dhone, Usmanabad, IN;

Bharat G. Adik, Ahmednagar, IN;

Neelima Khairatkar-Joshi, Thane, IN;

Daisy M. Shah, Mumbai, IN;

Malini Bajpai, Lucknow, IN;

Assignee:

Glenmark Pharmaceuticals S.A., , CH;

Attorney:

Blank Rome LLP

Primary Examiner:

Sun Jae Yoo

Int. Cl.
CPC ...
C07D 213/75 (2006.01); C07D 209/12 (2006.01); C07D 309/10 (2006.01); C07D 211/44 (2006.01); C07D 235/12 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 471/04 (2006.01); C07D 271/06 (2006.01); C07D 309/12 (2006.01); C07D 211/46 (2006.01); C07D 213/61 (2006.01); C07D 305/08 (2006.01); C07C 317/44 (2006.01); C07C 317/24 (2006.01); C07D 211/52 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07C 317/24 (2013.01); C07C 317/44 (2013.01); C07D 209/12 (2013.01); C07D 211/44 (2013.01); C07D 211/46 (2013.01); C07D 211/52 (2013.01); C07D 213/61 (2013.01); C07D 213/75 (2013.01); C07D 235/12 (2013.01); C07D 271/06 (2013.01); C07D 305/08 (2013.01); C07D 309/10 (2013.01); C07D 309/12 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07C 2101/02 (2013.01); C07C 2101/04 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01);
Abstract

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R, R, R, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

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