The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2017
Filed:
Mar. 14, 2014
Epizyme, Inc., Cambridge, MA (US);
Richard Chesworth, Concord, MA (US);
Oscar Miguel Moradei, Burlington, MA (US);
Gideon Shapiro, Gainesville, FL (US);
Kenneth W. Duncan, Westwood, MA (US);
Lorna Helen Mitchell, Cambridge, MA (US);
Lei Jin, Wellesley, MA (US);
Robert E. Babine, Carlsbad, CA (US);
Epizyme, Inc., Cambridge, MA (US);
Abstract
Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R, R, R, R, R, are as defined herein, and Ring HET is an optionally substituted 6,5-bicyclic heteroaryl ring system comprising 2 to 5 nitrogen atoms, inclusive, wherein the point of attachment is provided on the 6-membered ring of the 6,5-bicyclic heteroaryl ring system, and wherein the 6-membered ring is further substituted with a group of formula -L-R, wherein Land Rare as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.