The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 01, 2017

Filed:

Oct. 31, 2013
Applicants:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Eastern Michigan University, Ypsilanti, MI (US);

Inventors:

Daniel A. Lawrence, Ann Arbor, MI (US);

Cory Emal, Ann Arbor, MI (US);

Ashley Reinke, Ann Arbor, MI (US);

Shih-Hon Li, Ypsilanti, MI (US);

Mark Warnock, Brighton, MI (US);

Gregory Abernathy, Dublin, OH (US);

Assignees:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 243/26 (2006.01); C07C 69/84 (2006.01); C07C 259/06 (2006.01); C07C 271/16 (2006.01); C07C 275/64 (2006.01); C07C 311/17 (2006.01); C07C 311/29 (2006.01); C07C 311/48 (2006.01); C07C 311/49 (2006.01); C07D 417/04 (2006.01); C07C 323/60 (2006.01); C07D 249/08 (2006.01); C07C 233/13 (2006.01); C07C 233/56 (2006.01); C07D 261/18 (2006.01); C07C 235/34 (2006.01); C07C 235/46 (2006.01); C07D 271/113 (2006.01); C07D 277/34 (2006.01); C07D 207/48 (2006.01); C07C 251/76 (2006.01); C07D 209/08 (2006.01); C07D 209/34 (2006.01); C07D 213/42 (2006.01);
U.S. Cl.
CPC ...
C07C 69/84 (2013.01); C07C 233/13 (2013.01); C07C 233/56 (2013.01); C07C 235/34 (2013.01); C07C 235/46 (2013.01); C07C 243/26 (2013.01); C07C 251/76 (2013.01); C07C 259/06 (2013.01); C07C 271/16 (2013.01); C07C 275/64 (2013.01); C07C 311/17 (2013.01); C07C 311/29 (2013.01); C07C 311/48 (2013.01); C07C 311/49 (2013.01); C07C 323/60 (2013.01); C07D 207/48 (2013.01); C07D 209/08 (2013.01); C07D 209/34 (2013.01); C07D 213/42 (2013.01); C07D 249/08 (2013.01); C07D 261/18 (2013.01); C07D 271/113 (2013.01); C07D 277/34 (2013.01); C07D 417/04 (2013.01);
Abstract

The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.


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