The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 01, 2017

Filed:

Dec. 17, 2013
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Debra Ondeyka, Fanwood, NJ (US);

Xiaoxia Qian, New York, NY (US);

Petr Vachal, Summit, NJ (US);

Sriram Tyagarajan, Edison, NJ (US);

Cameron J. Smith, Lawrenceville, NJ (US);

Hong Li, Edison, NJ (US);

Jianming Bao, Princeton, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/423 (2006.01); A61K 31/444 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); C07D 413/14 (2006.01); C07D 413/06 (2006.01); C07D 263/52 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/423 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 263/52 (2013.01); C07D 413/06 (2013.01); C07D 413/14 (2013.01);
Abstract

Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing atherosclerosis. The chemical compounds that are disclosed cholesterol ester transfer protein (CETP) and are expected to have utility in raising HDL-C, lowering LDL-C, and in the treatment and prevention of atherosclerosis.


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