The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2017
Filed:
Jul. 31, 2008
Shuguang Zhang, Lexington, MA (US);
Andreas Mershin, Cambridge, MA (US);
Liselotte Kaiser, Stockholm, SE;
Brian Cook, Somerville, MA (US);
Johanna F. Graveland-bikker, Lexmond, NL;
Manu Prakash, Cambridge, MA (US);
David Kong, Lexington, MA (US);
Yael Maguire, Somerville, MA (US);
Shuguang Zhang, Lexington, MA (US);
Andreas Mershin, Cambridge, MA (US);
Liselotte Kaiser, Stockholm, SE;
Brian Cook, Somerville, MA (US);
Johanna F. Graveland-Bikker, Lexmond, NL;
Manu Prakash, Cambridge, MA (US);
David Kong, Lexington, MA (US);
Yael Maguire, Somerville, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.