The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 25, 2017

Filed:

Jun. 25, 2014
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Soo Sung Ko, Hockessin, DE (US);

Douglas G Batt, Wilmington, DE (US);

Myra Beaudoin Bertrand, Lambertville, NJ (US);

George Delucca, Pennington, NJ (US);

Charles M. Langevine, Brooklyn, NY (US);

Qingjie Liu, Newtown, PA (US);

Anurag S. Srivastava, Belle Mead, NJ (US);

Scott Hunter Watterson, Pennington, NJ (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 209/88 (2006.01); C07D 209/86 (2006.01); C07D 239/91 (2006.01); C07D 239/96 (2006.01); A61K 31/505 (2006.01); A61K 31/407 (2006.01); C07D 403/10 (2006.01); C07D 471/04 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/10 (2013.01); C07D 471/04 (2013.01); C07D 513/04 (2013.01);
Abstract

Disclosed are compounds of Formula (I); and salts thereof, wherein: Formula (II); Q is: Ris —C(CH)2OH, —NHC(=0)C(CH), —N(CH3)2, or —CHR; Ris CI or —CH; Ris H, F, or —CH; Ris H or —CH; Ris H, F, CI, or —OCH3 Ris H or F; and Rd is —OH, —OCH3, —NHC(=0)CH3, or fORMULA (III), Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.


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