The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 25, 2017

Filed:

Jun. 11, 2013
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Robert Mattrey, San Diego, CA (US);

Zhe Wu, San Diego, CA (US);

Emilia Olson, La Jolla, CA (US);

Joseph Wang, San Diego, CA (US);

Wei Gao, La Jolla, CA (US);

Christopher D. Malone, San Diego, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/05 (2006.01); A61B 8/08 (2006.01); A61K 49/22 (2006.01); A61B 8/00 (2006.01); A61F 2/00 (2006.01); A61F 2/02 (2006.01); A61M 25/01 (2006.01); A61B 90/00 (2016.01);
U.S. Cl.
CPC ...
A61B 8/481 (2013.01); A61B 8/0841 (2013.01); A61B 8/4483 (2013.01); A61B 90/39 (2016.02); A61F 2/0063 (2013.01); A61F 2/02 (2013.01); A61K 49/223 (2013.01); A61K 49/225 (2013.01); A61M 25/0108 (2013.01); A61B 2090/3925 (2016.02); A61F 2250/0096 (2013.01);
Abstract

A method and system are provided for detection of localized hydrogen peroxide within tissue by introducing a catalase-containing material into at location of interest, positioning an ultrasound transducer over the location, and generating an ultrasound image to detect microbubbles, where the presence of microbubbles indicate the presence of localized hydrogen peroxide. The catalase-coated surface may be the inner surface of a microtube, on the surface of or incorporated within a nanosphere or microsphere, or an implantable device.


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