The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

Mar. 13, 2013
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Jennifer E. Van Eyk, Baltimore, MD (US);

Allen Dale Everett, Glenwood, MD (US);

Zhicheng Jin, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/00 (2006.01); G01N 33/53 (2006.01); G01N 33/542 (2006.01); G01N 33/68 (2006.01); H01J 49/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6848 (2013.01); G01N 33/5306 (2013.01); G01N 33/6842 (2013.01); H01J 49/0027 (2013.01); H01J 49/0077 (2013.01); G01N 2440/18 (2013.01); G01N 2800/28 (2013.01);
Abstract

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.


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