The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

May. 23, 2014
Applicants:

Keio University, Minato-ku, Tokyo, JP;

University of Tsukuba, Tsukuba-shi, Ibaraki, JP;

Inventors:

Mutsuo Nuriya, Tokyo, JP;

Masato Yasui, Tokyo, JP;

Tatsuo Arai, Tsukuba, JP;

Atsuya Momotake, Tsukuba, JP;

Syun Fukushima, Tsukuba, JP;

Assignee:

KEIO UNIVERSITY, Minato-Ku, Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); G01N 21/63 (2006.01); C09B 29/036 (2006.01); C09B 29/08 (2006.01); C09B 44/12 (2006.01); C09B 29/42 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5091 (2013.01); C09B 29/0048 (2013.01); C09B 29/081 (2013.01); C09B 29/0803 (2013.01); C09B 29/0805 (2013.01); C09B 29/3639 (2013.01); C09B 44/126 (2013.01); G01N 21/636 (2013.01);
Abstract

Provided are a compound that generates an SHG signal but has suppressed generation of a TPF signal. Also provided is a cell examination method using the same. A compound for generating a second harmonic of light, the compound being an azobenzene derivative of formula (1), or a salt thereof. (R1 and R2 independently represent alkyl groups having 6-12 carbon atoms, and R3 to R18 independently represent substituents selected from hydrogen, halogens, alkyl groups, alkoxy groups, aryl groups, amino groups, hydroxyl groups, nitro groups, and cyano groups, but R5 and R6, R9 and R10, R13 and R14, and R17 and R18 may combine together and form a ring structure having 5-7 carbon atoms. X represents —N+R19R20R21, a sulfonyl group, a carboxyl group, or an —OR group. Here, R19, R20, and R21 independently represent straight-chain or branched alkyl groups having 1-5 carbon atoms, and —OR represents a monovalent polyalkylene oxide group terminated by an alkoxy group. a is 0 or 1, b is 0 or 1, and n is an integer of 1-10.)


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