The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2017
Filed:
Feb. 18, 2015
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Adva Mechaly, Ness-Ziona, IL;
Andrew J. McCluskey, Shrewsbury, MA (US);
R. John Collier, Wellesley Hills, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/02 (2006.01); A61K 39/07 (2006.01); A61K 39/00 (2006.01); C07K 14/32 (2006.01); C07K 16/32 (2006.01); C07K 14/21 (2006.01); C07K 14/25 (2006.01); C07K 14/28 (2006.01); C07K 14/33 (2006.01); C07K 14/34 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
C07K 14/32 (2013.01); C07K 14/21 (2013.01); C07K 14/25 (2013.01); C07K 14/28 (2013.01); C07K 14/33 (2013.01); C07K 14/34 (2013.01); C07K 16/2863 (2013.01); C07K 16/32 (2013.01); C07K 16/40 (2013.01); C07K 2317/73 (2013.01); C07K 2318/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/33 (2013.01); C07K 2319/55 (2013.01); C07K 2319/75 (2013.01);
Abstract
We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell target instead of its natural cell target. The system can be used for, e.g., targeted killing of undesired cells in a population of cells, such as cancer or overly active immune system cells.