The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2017
Filed:
Sep. 26, 2014
Applicant:
Geron Corporation, Menlo Park, CA (US);
Inventors:
Krisztina Pongracz, Oakland, CA (US);
Mahesh Ramaseshan, Sunnyvale, CA (US);
Assignee:
Geron Corporation, Menlo Park, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C07H 19/10 (2006.01); C07H 19/20 (2006.01); C07H 19/048 (2006.01); C07H 19/04 (2006.01); C07H 21/00 (2006.01); C07H 1/00 (2006.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); C07H 1/00 (2013.01); C07H 19/10 (2013.01); C07H 19/20 (2013.01);
Abstract
This invention relates to antisense oligonucleotides comprising at least one N3'→P5′ phosphorodiamidate linkage (NPN) in the backbone, and kits and pharmaceutical compositions thereof, useful for modulating gene expression involved in the pathogenesis of a disease. Also included are compounds useful as building blocks of said antisense oligonucleotides and methods of preparing said antisense oligonucleotides and building block compounds including NPN linkages.