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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9708338 B1

PDFFull Text
Date of Patent:
Jul. 18, 2017

Filed:

Mar. 22, 2016

Aromatic heterocyclylamine derivative having trpv4-inhibiting activity

Applicant:

Shionogi & Co., Ltd., Osaka, JP;

Inventors:

Akira Yukimasa, Osaka, JP;

Naoki Tsuno, Osaka, JP;

Motohiro Fujiu, Osaka, JP;

Hiroki Yamaguchi, Osaka, JP;

Hiromi Kudo, Osaka, JP;

Tatsuhiko Ueno, Osaka, JP;

Yusuke Ichihashi, Osaka, JP;

Takatsugu Inoue, Osaka, JP;

Shinji Suzuki, Osaka, JP;

Assignee:

SHIONOGI & CO., LTD., Osaka, JP;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Brenda Coleman

Int. Cl.
CPC ...
A61K 31/443 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/08 (2006.01); C07D 498/08 (2006.01); C07D 513/08 (2006.01); C07D 491/08 (2006.01); C07D 491/107 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 491/10 (2006.01); C07D 498/10 (2006.01);
U.S. Cl.
CPC ...
C07D 491/08 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01); C07D 491/10 (2013.01); C07D 491/107 (2013.01); C07D 498/08 (2013.01); C07D 498/10 (2013.01); C07D 513/08 (2013.01);
Abstract

The present invention is related to a compound represented by formula (I) wherein —X— is —NH— or —S—; —Z— is —O— or —S—; R, Rand Rare each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; Ris a cyano, substituted or unsubstituted amino, or the like; Ris each independently a halogen; b is 0 or 1; or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

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