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For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9708336 B1

PDFFull Text
Date of Patent:
Jul. 18, 2017

Filed:

Jan. 16, 2015

Metallo-beta-lactamase inhibitors

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Mihir Mandal, Westfield, NJ (US);

Haifeng Tang, Metuchen, NJ (US);

Li Xiao, Cranbury, NJ (US);

Jing Su, Scotch Plains, NJ (US);

Guoqing Li, Belle Mead, NJ (US);

Shu-Wei Yang, Edison, NJ (US);

Weidong Pan, Hillsborough, NJ (US);

Haiqun Tang, Belle Mead, NJ (US);

Reynalda DeJesus, East Brunswick, NJ (US);

Jacqueline Hicks, Scotch Plains, NJ (US);

Matthew Lombardo, Flemington, NJ (US);

Hong Chu, Livingston, NJ (US);

William Hagmann, Westfield, NJ (US);

Alex Pasternak, Princeton, NJ (US);

Xin Gu, Scotch Plains, NJ (US);

Jinlong Jiang, Scotch Plains, NJ (US);

Shuzhi Dong, Plainsboro, NJ (US);

Fa-Xiang Ding, Staten Island, NY (US);

Clare London, Chatham, NJ (US);

Dipshikha Biswas, Woodbridge, NJ (US);

Katherine Young, Metuchen, NJ (US);

David N. Hunter, Scotch Plains, NJ (US);

Zhiqiang Zhao, Scotch Plains, NJ (US);

Dexi Yang, Livingston, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Alysia A. Finnegan

Gloria M. Fuentes

Primary Examiner:

Brian J Davis

Int. Cl.
CPC ...
C07D 491/048 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/5025 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); C07D 401/04 (2006.01); C07D 409/10 (2006.01); C07D 487/04 (2006.01); C07D 471/10 (2006.01); C07D 471/04 (2006.01); C07D 451/04 (2006.01); C07D 417/14 (2006.01); C07D 417/10 (2006.01); C07D 413/10 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/10 (2006.01); C07D 403/10 (2006.01); C07D 401/10 (2006.01); C07D 413/14 (2006.01); C07D 405/14 (2006.01); A61K 31/41 (2006.01); C07D 257/04 (2006.01); A61K 31/197 (2006.01); A61K 31/407 (2006.01); A61K 31/4155 (2006.01); A61K 31/4178 (2006.01); A61K 31/4192 (2006.01); A61K 31/422 (2006.01); A61K 31/4245 (2006.01); A61K 31/427 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); A61K 31/197 (2013.01); A61K 31/407 (2013.01); A61K 31/41 (2013.01); A61K 31/4155 (2013.01); A61K 31/4178 (2013.01); A61K 31/4192 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5025 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 257/04 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 405/10 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/10 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 417/10 (2013.01); C07D 417/14 (2013.01); C07D 451/04 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

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