The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

Oct. 01, 2015
Applicant:

Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, JP;

Inventors:

Takao Abe, Kanagawa, JP;

Takeshi Furuuchi, Kanagawa, JP;

Yoshiaki Sakamaki, Kanagawa, JP;

Seiichi Inamura, Kanagawa, JP;

Akihiro Morinaka, Kanagawa, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/06 (2006.01); C07D 295/00 (2006.01); C07D 471/08 (2006.01); C07D 211/60 (2006.01); A61K 45/06 (2006.01); A61K 31/43 (2006.01); A61K 31/545 (2006.01); A61K 31/546 (2006.01); A61K 31/439 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01); A61K 31/437 (2006.01); A61K 31/407 (2006.01); A61K 31/4162 (2006.01); A61K 31/427 (2006.01); C07F 7/08 (2006.01);
U.S. Cl.
CPC ...
C07D 471/08 (2013.01); A61K 31/407 (2013.01); A61K 31/4162 (2013.01); A61K 31/427 (2013.01); A61K 31/43 (2013.01); A61K 31/437 (2013.01); A61K 31/439 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/5377 (2013.01); A61K 31/545 (2013.01); A61K 31/546 (2013.01); A61K 45/06 (2013.01); C07D 211/60 (2013.01); C07F 7/0812 (2013.01); Y02P 20/55 (2015.11);
Abstract

A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): wherein A represents Ra(Rb)N— or RcO—; B represents NH or NCalkyl; C represents benzyl, H or SOM, wherein M represents H, an inorganic or an organic cation; Ra and Rb represent H, Calkyl or acyl; Rc represents Calkyl or a heterocyclyl; A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents Calkyl, O═, or Rg-(CH)—, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdOS—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents Calkyl or MO—; Re and Rf represent H or Calkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.


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