The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2017
Filed:
Dec. 22, 2015
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Brian E. Fink, Yardley, PA (US);
Yufen Zhao, Pennington, NJ (US);
Robert M. Borzilleri, New Hope, PA (US);
Liping Zhang, East Windsor, NJ (US);
Kyoung S. Kim, Vancouver, WA (US);
Muthoni G. Kamau, Lawrenceville, NJ (US);
Andrew J. Tebben, New Hope, PA (US);
Yong Zhang, West Windsor, NJ (US);
Andrew F. Donnell, West Windsor, NJ (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4709 (2006.01); A61K 31/501 (2006.01); C07D 487/04 (2006.01); C07D 471/04 (2006.01); A61K 31/5377 (2006.01); A61K 31/437 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/541 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/437 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); C07D 487/04 (2013.01);
Abstract
The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.