The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

Jan. 12, 2016
Applicants:

Array Biopharma Inc., Boulder, CO (US);

Genentech, Inc., South San Francisco, CA (US);

Inventors:

James F. Blake, Boulder, CO (US);

Mark Joseph Chicarelli, Boulder, CO (US);

Rustam Ferdinand Garrey, Boulder, CO (US);

John Gaudino, Boulder, CO (US);

Jonas Grina, Boulder, CO (US);

David A. Moreno, Boulder, CO (US);

Peter J. Mohr, Boulder, CO (US);

Li Ren, Boulder, CO (US);

Jacob Schwarz, South San Francisco, CA (US);

Huifen Chen, South San Francisco, CA (US);

Kirk Robarge, South San Francisco, CA (US);

Aihe Zhou, South San Francisco, CA (US);

Assignees:

Array BioPharma Inc., Boulder, CO (US);

Genentech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/53 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01); C07F 9/6558 (2006.01); C07D 403/04 (2006.01); A61K 31/513 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07F 9/65586 (2013.01); A61K 31/444 (2013.01); A61K 31/513 (2013.01); A61K 31/53 (2013.01); C07D 403/04 (2013.01);
Abstract

Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.


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