The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

Sep. 05, 2012
Applicants:

Seong Keun Kim, Seoul, KR;

Seung Yang, Ii, Seoul, KR;

Seon Jin Hwang, Seoul, KR;

Jung Eun Lee, Incheon, KR;

Jong Woo Lee, Seoul, KR;

Jun Hee Kang, Seoul, KR;

Eun Hak Lim, Seoul, KR;

Inventors:

Seong Keun Kim, Seoul, KR;

Seung Yang, II, Seoul, KR;

Seon Jin Hwang, Seoul, KR;

Jung Eun Lee, Incheon, KR;

Jong Woo Lee, Seoul, KR;

Jun Hee Kang, Seoul, KR;

Eun Hak Lim, Seoul, KR;

Assignee:

SNU R&DB Foundation, Seoul, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 49/248 (2006.01); C07C 49/255 (2006.01); C07H 15/207 (2006.01); C09K 11/06 (2006.01); C07H 15/203 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
C07C 49/248 (2013.01); A61K 49/0021 (2013.01); A61K 49/0052 (2013.01); A61K 49/0054 (2013.01); C07C 49/255 (2013.01); C07H 15/203 (2013.01); C09K 11/06 (2013.01); C09K 2211/1011 (2013.01);
Abstract

The present invention provides a water-soluble fluorescent compound of resveratrone 6-O-β-glucoside [(E)-4-(8-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphthalen-2-yl)but-3-en-2-one] and its derivatives of Formula 1 which have at least one water-soluble substituent, and a method for preparing the same by a photochemical reaction of resveratrol 3-O-β-glucoside and its derivatives of having Formula 3 which are not fluorescent. Said new water-soluble fluorescent compounds has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity, and can be usefully utilized in fields that requires water-soluble fluorescent characteristics (diagnosis, fluorescent probe, in vivo imaging, display, etc.).


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