The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 18, 2017

Filed:

Dec. 15, 2015
Applicant:

Florida Atlantic University Research Corporation, Boca Raton, FL (US);

Inventors:

Janet C. Blanks, Boca Raton, FL (US);

Howard M. Prentice, Boca Raton, FL (US);

C. Kathleen Dorey, Roanoke, VA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/86 (2006.01); C12N 5/0793 (2010.01); C12N 5/079 (2010.01); C12N 15/63 (2006.01); A61K 38/39 (2006.01); A61K 9/00 (2006.01); C07K 14/78 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 9/0048 (2013.01); A61K 38/39 (2013.01); A61K 48/005 (2013.01); A61K 48/0058 (2013.01); C07K 14/78 (2013.01); C12N 5/062 (2013.01); C12N 5/0621 (2013.01); C12N 7/00 (2013.01); C12N 15/63 (2013.01); C12N 15/86 (2013.01); C12N 2710/10041 (2013.01); C12N 2710/10071 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01); C12N 2830/002 (2013.01); C12N 2830/008 (2013.01); C12N 2830/32 (2013.01);
Abstract

The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.


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