The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2017
Filed:
Dec. 27, 2012
Creabilis Therapeutics S.p.a., Colleretto Giacosa, IT;
Silvio Traversa, Palazzo Canavese, IT;
Chiara Lorenzetto, Villafranca Piemonte, IT;
Valentina Mainero, Ivrea, IT;
Sebastiano Morena, Chivasso, IT;
Silvano Fumero, Ivrea, IT;
Luca Beccaria, Ivrea, IT;
CREABILIS THERAPEUTICS S.R.L., Colleretto Giacosa, IT;
Abstract
The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE.